Oral anti-tuberculosis drugs: An urgent medication reconciliation at hospitals in Indonesia

  • Fauna Herawati | fauna@staff.ubaya.ac.id Department of Clinical and Community Pharmacy, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Surabaya; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok , Indonesia. https://orcid.org/0000-0002-8355-955X
  • Eka Yuliantini Fahmi Department of Clinical and Community Pharmacy, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Surabaya, Indonesia.
  • Noer Aulia Pratiwi Department of Clinical and Community Pharmacy, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Surabaya, Indonesia.
  • Dewi Ramdani Department of Pharmacy, RSU Haji, Surabaya, Indonesia.
  • Abdul Kadir Jaelani Department of Pharmacy, RSUD Bangil, Pasuruan, Indonesia.
  • Rika Yulia Department of Clinical and Community Pharmacy, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Surabaya, Indonesia.
  • Retnosari Andrajati Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.

Abstract

Background: Four oral anti-tuberculosis drugs are conceived to be the most effective ones to eradicate Mycobacterium tuberculosis bacteria and to obviate the resistant organisms. However, the patients' adherence and medication discrepancies are obstacles to achieving the goal. This study aimed to define the anti-tuberculosis drugs used in the hospitals and to detect the discrepancies in the continuity of the tuberculosis treatment.
Design and Methods: This retrospective cross-sectional study was based on medical records of adult patients, and was conducted in two district tertiary care hospitals. Only 35 out of 136 patient records from Hospital A and 33 out of 85 records from Hospital B met the inclusion criteria.
Results: The most common systemic anti-infective drugs in the study were ceftriaxone (51.80 DDD/100 patient-days) used in Hospital A and isoniazid (59.53 DDD/100 patient-days) used in Hospital B. The number of rifampicin prescriptions was less than that of isoniazid. Each patient received an average of two DDD/100 patient-days, which is an under dosage for an effective treatment.
Conclusion: This study showed a medication discrepancy of Tuberculosis therapy. Tuberculosis patients’ medical histories are not under the full attention of treating physicians wherever they are admitted. Thus, medication reconciliation is needed to accomplish the goal of a Tuberculosis-free world in 2050.

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Published
2021-08-11
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Original Articles
Keywords:
Defined daily dose (DDD), tuberculosis drug, medication reconciliation, drug utilization study, drug treatment, prevention/control program, infection (lung disease)
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How to Cite
Herawati, F., Fahmi, E. Y., Pratiwi, N. A., Ramdani, D., Jaelani, A. K., Yulia, R., & Andrajati, R. (2021). Oral anti-tuberculosis drugs: An urgent medication reconciliation at hospitals in Indonesia. Journal of Public Health Research, 10(3). https://doi.org/10.4081/jphr.2021.1896